698
Participants
Start Date
September 1, 2025
Primary Completion Date
December 31, 2029
Study Completion Date
June 30, 2030
The novel care pathway intervention
The pathway uses already-ascertained data, bioMérieux Spotfire testing, and POC CRP testing to stratify patients into risk categories. The first step in the pathway will be POC CRP testing; children with CRP \> 60 mg/L will be deemed 'appreciable risk', whereas those with CRP \< 20 mg/L will be deemed 'low risk'. The CRP cut-offs of 20mg/L (more sensitive) and 60mg/L (more specific) were selected after reviewing the literature, with particular emphasis on meta-analyses; other large recent studies have also used 60mg/L as an upper cut-off for bacterial infection. Participants with CRP between 20-60mg/L will be categorized further to identify children either more likely to have bacterial pneumonia or more intolerant of misclassification. 'If they have O2 saturation \<95% AND tachypnoea as per age-specific norms, they will be 'appreciable risk' (\>60 bpm for age \<1 y, \>50 bpm for 1-2 y, \>40 bpm for 2-4 y, and \>30 bpm for \>4 y).
Usual Care Alone
Participants will be recruited in the ED and will be managed as per the treating clinician; the study team will not influence management.
Alberta Children's hospital, Calgary
Stollery Children's Hospital, Edmonton
BC Children's Hospital, Vancouver
McMaster Children's Hospital, Hamilton
Children's Hospital of Eastern Ontario (CHEO), Ottawa
The Hospital for Sick Children, Toronto
Jeffrey
OTHER