Trial of Varenicline With Nicotine Lozenges and a Smartphone Medication Adherence Intervention for Smoking Cessation

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

496

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

June 30, 2029

Study Completion Date

June 30, 2029

Conditions
Smoking Cessation
Interventions
DRUG

Varenicline (VAR)

13 weeks of varenicline

DRUG

Nicotine lozenge (NRT)

12 weeks of nicotine lozenges

BEHAVIORAL

Smartphone intervention with adherence components (ADHERE)

Smartphone-based smoking cessation intervention with adherence components

BEHAVIORAL

Smartphone intervention without adherence components (NO ADHERE)

Smartphone-based smoking cessation intervention without adherence components

BEHAVIORAL

Telephone Counseling

Up to 6 telephone counseling sessions with a tobacco treatment specialist

Trial Locations (1)

73104

TSET Health Promotion Research Center, Oklahoma City

Sponsors

Collaborators (1)

All Listed Sponsors
lead

University of Oklahoma

OTHER

collaborator

National Cancer Institute (NCI)

NIH

collaborator

Brown University

OTHER

collaborator

Thomas Jefferson University

OTHER

collaborator

Sidney Kimmel Cancer Center at Thomas Jefferson University

OTHER

collaborator

OU Health Stephenson Cancer Center

UNKNOWN