Neoadjuvant Oral Paclitaxel Plus Subcutaneous Pertuzumab/Trastuzumab in Patients With HER2-positive Breast Cancer

NARecruitingINTERVENTIONAL
Enrollment

112

Participants

Timeline

Start Date

August 15, 2025

Primary Completion Date

December 30, 2026

Study Completion Date

June 30, 2029

Conditions
Breast Cancers
Interventions
DRUG

Paclitaxel oral solution plus Subcutaneous Pertuzumab/Trastuzumab

"Patients who meet the inclusion criteria will be enrolled and given paclitaxel oral solution and subcutaneous pertuzumab/trastuzumab for neoadjuvant treatment.~Paclitaxel oral solution: 200mg/m2 po bid, D1,D8,D15, q3w. Subcutaneous pertuzumab/trastuzumab: 1200 mg pertuzumab plus 600 mg trastuzumab loading dose in 15 mL, followed by 600 mg pertuzumab plus 600 mg trastuzumab maintenance doses in 10 mL, q3w."

Trial Locations (9)

Unknown

NOT_YET_RECRUITING

Peking University Cancer Hospital, Beijing

NOT_YET_RECRUITING

Guangdong Women and children Hospital, Guangzhou

RECRUITING

Sun Yat-sen Memorial Hospital, Guangzhou

NOT_YET_RECRUITING

Cancer Hospital of Shantou University Medical College, Shantou

NOT_YET_RECRUITING

Guangxi Provincial Cancer Hospital, Nanning

NOT_YET_RECRUITING

The Affiliated Hospital of Guizhou Medical University, Guiyang

NOT_YET_RECRUITING

Hainan Central Hospital, Haikou

NOT_YET_RECRUITING

the First Affiliated Hospital of Wenzhou Medical University, Wenzhou

NOT_YET_RECRUITING

Peking University Shenzhen Hospita, Shenzhen

All Listed Sponsors
collaborator

Peking University Cancer Hospital & Institute

OTHER

collaborator

Peking University Shenzhen Hospital

OTHER

collaborator

Hainan People's Hospital

OTHER

collaborator

The Affiliated Hospital Of Guizhou Medical University

OTHER

collaborator

Nanfang Hospital, Southern Medical University

OTHER

collaborator

Guangdong Women and Children Hospital

OTHER

collaborator

Affiliated Cancer Hospital of Shantou University Medical College

OTHER

collaborator

First Affiliated Hospital of Wenzhou Medical University

OTHER

collaborator

Cancer Hospital of Guangxi Medical University

OTHER

lead

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

OTHER

NCT07095023 - Neoadjuvant Oral Paclitaxel Plus Subcutaneous Pertuzumab/Trastuzumab in Patients With HER2-positive Breast Cancer | Biotech Hunter | Biotech Hunter