NCT07093346 - The Impact of Pectin Supplementation on Systematic Inflammation Pathway, Gut Microbiome, and Metabolic Health in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

June 10, 2025

Primary Completion Date

March 31, 2027

Study Completion Date

March 31, 2027

Conditions

Nonalcoholic Fatty Liver DiseaseNonalcoholic Fatty Liver Disease (NAFLD)MASLD - Metabolic Dysfunction-Associated Steatotic Liver DiseaseMASLDNAFLDMetabolic Dysfunction-Associated Steatotic Liver DiseaseNAFLD (Nonalcoholic Fatty Liver Disease)NAFLD (Non-alcoholic Fatty Liver Disease)NAFLD - Non-Alcoholic Fatty Liver DiseaseNAFLD - Nonalcoholic Fatty Liver Disease

Interventions

DIETARY_SUPPLEMENT

Pectin

15g of pectin with 10g of cocoa powder added as flavour were randomly allocated to eligible participants.

OTHER

Cocoa Powder

10g of cocoa powder served as the control/ placebo to compare the effects observed with pectin.

DIAGNOSTIC_TEST

Magnetic Resonance Imaging with Contrast

To validate MRI scans as a tool to assess intestinal wall thickness to indicate gut permeability on MASLD patients, the investigators will scan 15 healthy volunteers twice, at baseline and after 6 weeks, and then compare their results with MASLD participant results at baseline and after 6 weeks.

Trial Locations (3)

NG7 2QX

RECRUITING

Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham

NG7 2UH

RECRUITING

Nottingham Clinical Research Facility at Nottingham University Hospitals NHS Trust, Nottingham

RECRUITING

University of Nottingham, Nottingham

All Listed Sponsors

collaborator

Nottingham University Hospitals NHS Trust

OTHER

lead

University of Nottingham

OTHER