Evaluating Treatment Strategies for p53 Mutant Oral Cancer and Oral Cancer Precursors: A Randomized Controlled Trial

Clear margin excision of the lesion under local anesthetic, with re-excision for p53-positive margins.

Clear margin excision of the lesion under local anesthetic, with re-excision until severe/CIS margins are clear

Excision of the lesion ensuring final negative p53 and severe/CIS margins

Excision of primary lesions with 5+mm margins and immediate elective neck dissection

Excision of primary lesion with 5+mm margins and close follow up with salvage elective neck dissection if development of nodal disease