Short-Term Nutritional Enhancement Combined With Health Education in Postoperative Colorectal Cancer Patients: A Randomized Controlled Trial

NARecruitingINTERVENTIONAL
Enrollment

360

Participants

Timeline

Start Date

October 10, 2024

Primary Completion Date

October 10, 2029

Study Completion Date

October 10, 2030

Conditions
Colorectal Cancer (Diagnosis)Malnutrition or Risk of Malnutrition
Interventions
DIETARY_SUPPLEMENT

Personalized Oral Nutritional Supplementation

Participants receive individualized oral nutritional supplementation based on energy and protein requirements, calculated using the Harris-Benedict equation and body weight (1.2-1.5 g protein/kg/day). The supplement may include complete nutrition powder, whey protein powder, and compound multivitamins. The intervention is prescribed and monitored by a clinical nutrition team and adjusted every 3 days during the 14-day intervention phase. The goal is to ensure both energy and protein intake targets are met. Supplements are administered in addition to standard meals.

DRUG

Personalized Parenteral Nutritional Supplementation

For participants unable to meet nutritional goals through oral intake, parenteral nutrition is administered intravenously. The formulation includes amino acids, glucose, lipids, electrolytes, trace elements, and vitamins. Dosages are aligned with those of the enteral nutrition group, ensuring a consistent intake of energy and protein (1.2-1.5 g/kg/day protein). Formulation and administration follow standardized hospital protocols and are supervised by the nutrition support team.

BEHAVIORAL

Structured Nutrition-Focused Health Education

"Participants receive structured health education focused on nutrition, physical activity, and psychological well-being. The education is delivered over 14 days using a digital Internet Plus platform, featuring weekly videos, interactive Q\&A sessions, and guidance from a multidisciplinary nutrition support team. Educational content covers dietary recommendations, exercise safety, stress management, and post-treatment recovery strategies. Materials are updated weekly, and participants may access them remotely via smartphone or tablet. This intervention aims to improve nutrition knowledge, adherence, and health behavior change."

Trial Locations (1)

710000

RECRUITING

Xi 'an Jiaotong University, Xi'an

All Listed Sponsors
lead

Xiaoqin Luo

OTHER