Phase Ib/II Study of Vebreltinib With Furmonertinib in NSCLC Patients With c-Met Amplification After EGFR-TKI Failure

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

April 8, 2025

Primary Completion Date

April 30, 2027

Study Completion Date

April 30, 2028

Conditions
Non Small Cell Lung Cancer NSCLC
Interventions
DRUG

Vebreltinib combined with Furmonertinib

Vebreltinib 100mg/1500mg/200mg oral twice daily combined with Furmonertinib 80mg oral once daily

DRUG

Vebreltinib combined with Furmonertinib

Vebreltinib 100mg/1500mg/200mg oral twice daily combined with Furmonertinib 80mg oral once daily. Based on the safety data from the completed dose cohorts, the investigators will involve the selection of 1-2 dose cohorts for further study. Approximately 10 additional subjects will be enrolled in the selected dose expansion cohort to determine the recommended dose for Phase II clinical trials.

DRUG

Vebreltinib combined with Furmonertinib

RP2D of Vebreltinib as determined during Phase Ib oral twice daily combined with Furmonertinib 80mg oral once daily

Trial Locations (12)

100142

RECRUITING

Peking University Cancer Hospital & Institute, Beijing

Unknown

NOT_YET_RECRUITING

Ordos Central Hospital, Neimeng

NOT_YET_RECRUITING

Peking University Cancer Hospital (Inner Mongolia Campus), Neimeng

NOT_YET_RECRUITING

Affiliated Hospital of Hebei University, Baoding

RECRUITING

Baotou Cancer Hospital, Baotou

NOT_YET_RECRUITING

Beijing Chest Hospital, Capital Medical University, Beijing

NOT_YET_RECRUITING

Beijing Daxing District People's Hospital, Beijing

NOT_YET_RECRUITING

Peking Union Medical College Hospital, Beijing

NOT_YET_RECRUITING

Peking University People's Hospital, Beijing

NOT_YET_RECRUITING

Peking University Third Hospital, Beijing

NOT_YET_RECRUITING

The Second Hospital of Dalian Medical University, Dalian

NOT_YET_RECRUITING

Tianjin Medical University Cancer Institute & Hospital, Tianjin

All Listed Sponsors
lead

Peking University Cancer Hospital & Institute

OTHER