A Study Testing a New Heart Scan Method to Improve Pacemaker Treatment for Heart Failure

NANot yet recruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

July 31, 2030

Study Completion Date

July 31, 2030

Conditions
Cardiac Resynchronisation Therapy (CRT)Heart Failure
Interventions
OTHER

EF1 guided CRT optimisation

In the EF1-guided optimisation group, the settings of the CRT device are adjusted to maximise early heart pumping efficiency, measured by a parameter called first-phase ejection fraction (EF1). Depending on the patient's heart rhythm, either the timing between heart chambers (AV or VV delay) is adjusted in small steps. The device setting that gives the best EF1 reading is chosen to help improve the heart's response to CRT.

OTHER

Standard of Care (SOC)

This group will receive standard of care for their health condition and CRT management.

Trial Locations (1)

Unknown

Guy's and St. Thomas' NHS Foundation Trust, London

All Listed Sponsors
collaborator

Guy's and St Thomas' NHS Foundation Trust

OTHER

collaborator

The Leeds Teaching Hospitals NHS Trust

OTHER

collaborator

King's College Hospital NHS Trust

OTHER

collaborator

Barts Helth NHS Trust

UNKNOWN

lead

King's College London

OTHER

NCT07084467 - A Study Testing a New Heart Scan Method to Improve Pacemaker Treatment for Heart Failure | Biotech Hunter | Biotech Hunter