400
Participants
Start Date
August 1, 2025
Primary Completion Date
July 31, 2030
Study Completion Date
July 31, 2030
EF1 guided CRT optimisation
In the EF1-guided optimisation group, the settings of the CRT device are adjusted to maximise early heart pumping efficiency, measured by a parameter called first-phase ejection fraction (EF1). Depending on the patient's heart rhythm, either the timing between heart chambers (AV or VV delay) is adjusted in small steps. The device setting that gives the best EF1 reading is chosen to help improve the heart's response to CRT.
Standard of Care (SOC)
This group will receive standard of care for their health condition and CRT management.
Guy's and St. Thomas' NHS Foundation Trust, London
Guy's and St Thomas' NHS Foundation Trust
OTHER
The Leeds Teaching Hospitals NHS Trust
OTHER
King's College Hospital NHS Trust
OTHER
Barts Helth NHS Trust
UNKNOWN
King's College London
OTHER