ECP-DL Cell Infusion for Induction in Living Donor Kidney (LDK) Transplants

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

September 30, 2025

Primary Completion Date

August 25, 2027

Study Completion Date

August 25, 2028

Conditions
Kidney Transplant Failure and RejectionKidney Transplant; Complications
Interventions
DEVICE

ECP-DL treated mononuclear cell infusion

Participants in this study will undergo the infusion of donor white blood cells treated with ECP one week before their living donor kidney transplant, combined with standard of care antirejection medications. You will also then have ECP treatments using your own blood on two consecutive days once per month for 6 months. This combination is intended to cause your immune system to create a state called tolerance to the donor kidney. The ECP procedure has not been approved to prevent rejection after kidney transplant and the use of ECP to prevent rejection of transplanted organs is experimental, and is not a part of standard treatment which is based on the long term use of anti-rejection drugs such as tacrolimus (Prograf), everolimus, and prednisone.

All Listed Sponsors
lead

Northwestern University

OTHER