Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD)

Not yet recruitingOBSERVATIONAL
Enrollment

100

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

July 1, 2030

Study Completion Date

July 1, 2030

Conditions
Obesity and Obesity-related Medical ConditionsDiabetesAtherosclerotic DiseaseHeart FailureMASHSarcopeniaOsteoporosisHyperparathyroidismHypoparathyroidismIschemic Heart DiseaseCystic Fibrosis (CF)Chronic Kidney Disease(CKD)OsteopeniaCachexia
Interventions
OTHER

Endothelial cell collection

Participants may opt to have testing performed including blood sampling, urine sampling, intravenous catheter placement with endothelial cell collection, oral glucose tolerance test, consuming a test meal, having imaging performed such as MRI, DEXA, MRS, having adipose (fat) or muscle biopsies, or non-invasive endothelial function testing to investigate use of different assays, different sample treatment approaches to determine optimal conditions that produce the most accurate and reproducible results, and/or repeat testing on different days or with different equipment that measures the same variable.

Trial Locations (1)

65211

University of Missouri-Columbia, Columbia

All Listed Sponsors
lead

Bettina Mittendorfer

OTHER