JS203 Combination Regimens in B-Cell Non-Hodgkin's Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

180

Participants

Timeline

Start Date

August 17, 2025

Primary Completion Date

April 6, 2027

Study Completion Date

April 6, 2027

Conditions
B-cell Non-Hodgkin's Lymphoma
Interventions
DRUG

JS203 in combination with gemcitabine and oxaliplatin

Gemcitabine and oxaliplatin 8 cycles (Q3W) and JS203 (21 days/cycle) Cycle 1 QW,Cycle 2 and therafter Q3W until progression or unacceptable toxicity.

DRUG

JS203 in combination with ifosfamide, carboplatin and etoposide

Ifosfamide, carboplatin and etoposide, 3 cycles (Q3W) and JS203, Cycle 1 QW, Cycle 2 and therafter Q3W until trasnplant, progression or unacceptable toxicity.

DRUG

JS203 in combination with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone

Rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone 6 cycles (Q3W) and JS203, 8 cycles (21 days/cycle), Cycle 1 QW, Cycle 2 to Cycle 8 Q3W.

DRUG

JS203 combined with lenalidomide

lenalidomide,12 cycles, Cycle 1(Q3W), Cycle 2 to Cycle 12 (Q4W) and JS203, 12 cycles, Cycle 1 (21 days/cycle) QW, Cycle 2 to Cycle 12 (28 days/cycle) Q4W.

Trial Locations (1)

100142

RECRUITING

Beijing Cancer Hospital, Beijing

All Listed Sponsors
lead

Shanghai Junshi Bioscience Co., Ltd.

OTHER

NCT07081022 - JS203 Combination Regimens in B-Cell Non-Hodgkin's Lymphoma | Biotech Hunter | Biotech Hunter