Chidamide Combined With Brentuximab Vedotin Regimen for CD30+ PTCL Patients

NARecruitingINTERVENTIONAL
Enrollment

47

Participants

Timeline

Start Date

November 1, 2024

Primary Completion Date

August 1, 2028

Study Completion Date

November 1, 2028

Conditions
CD30+ Peripheral T-cell Lymphoma
Interventions
DRUG

Induction therapy-3 cycles of BvC (Brentuximab vedotin plus Chidamide)

"3 cycles of BvC treatment for all enrolled patients.~Brentuximab vedotin; Specification: 50mg per vial; 1.8mg/kg qd d1 every 3 weeks, ivgtt.;~Chidamide; Specification: 5mg per tablet; 20mg biw for 2 weeks every 3 weeks, po.;"

DRUG

Consolidation therapy- 3 or 6 cycles of BvC(Brentuximab vedotin plus chidamide)

"Consolidation therapy( For patients who achieved CR after induction therapy, 3 cycles of additional BvC treatment; For patients who achieved PR after induction therapy, 6 cycles of additional BvC treatment).~Brentuximab vedotin; Specification: 50mg per vial; 1.8mg/kg qd d1 every 3 weeks, ivgtt.;~Chidamide; Specification: 5mg per tablet; 20mg biw for 2 weeks every 3 weeks, po.;~Maintenance therapy chidamide (20mg biw for 2 weeks every 3 weeks, po.) for ≥2 years"

DRUG

Maintenance therapy-chidamide

Chidamide (20mg biw for 2 weeks every 3 weeks, po.) for ≥2 years

Trial Locations (1)

215006

RECRUITING

The First Affiliated Hospital of Soochow University, Suzhou

All Listed Sponsors
lead

The First Affiliated Hospital of Soochow University

OTHER