Safety and Tolerability of CVHNLC Plus Pembrolizumab in Patients With Squamous Non Small-Cell Lung Cancer (sqNSCLC)

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

36

Participants

Timeline

Start Date

July 30, 2025

Primary Completion Date

December 31, 2029

Study Completion Date

December 31, 2029

Conditions
Squamous NSCLC
Interventions
BIOLOGICAL

CV09070101 mRNA vaccine (CVHNLC) 50 µg

CVHNLC will be administered as in IM injection (4x in induction treatment period, than during main treatment period every 3 weeks) plus pembrolizumab (3-weekly)

BIOLOGICAL

CV09070101 mRNA vaccine (CVHNLC) 100 µg

CVHNLC will be administered as in IM injection (4x in induction treatment period, than during main treatment period every 3 weeks) plus pembrolizumab (3-weekly)

BIOLOGICAL

CV09070101 mRNA vaccine (CVHNLC) 200 µg

CVHNLC will be administered as in IM injection (4x in induction treatment period, than during main treatment period every 3 weeks) plus pembrolizumab (3-weekly)

BIOLOGICAL

CV09070101 mRNA vaccine (CVHNLC) 400 µg

CVHNLC will be administered as in IM injection (4x in induction treatment period, than during main treatment period every 3 weeks) plus pembrolizumab (3-weekly)

BIOLOGICAL

CV09070101 mRNA vaccine (CVHNLC) 400 µg

CVHNLC will be administered as in IM injection (4x in induction treatment period, than during main treatment period every 3 weeks) plus pembrolizumab (3-weekly) and carboplatin/paclitaxel (3-weekly)

Trial Locations (13)

22031

Virginia Cancer Center, Fairfax

23298

Virginia Commonwealth University, Massey Comprehensive Cancer Center, McGlothlin Medical Education Center, Richmond

Unknown

AP-HM - Hôpital Nord, Marseille

Institut Curie - Hôpital de Paris, Paris

CHU de Rennes - Hôpital Pontchaillou, Rennes

Institut de Cancerologie de l'Ouest - Hôpital Saint Herblain - PPDS, Saint-Herblain

Institut Claudius Regaud - PPDS, Toulouse

Gustave Roussy, Villejuif

Hospital Quironsalud Barcelona -NEXT Oncology, Barcelona

Hospital Universitari Vall d´Hebron -Instituto de Investigacion Oncologica Vall dHebron (VHIO), Barcelona

Hospital Universitario Fundacion Jimenez Diaz - START MADRID, Madrid

Hospital Universitario HM Sanchinarro - CIOCC - START MADRID, Madrid

Hospital Regional Universitario Virgen de la Victoria, Málaga

Sponsors

Lead Sponsor

All Listed Sponsors
lead

CureVac

INDUSTRY

NCT07073183 - Safety and Tolerability of CVHNLC Plus Pembrolizumab in Patients With Squamous Non Small-Cell Lung Cancer (sqNSCLC) | Biotech Hunter | Biotech Hunter