CD19 CAR-T Cell Infusion as Consolidation Therapy in Adolescent and Adult Patients With Acute B-ALL Ineligible for Allogeneic HSCT: A Clinical Study

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

July 19, 2025

Primary Completion Date

March 19, 2027

Study Completion Date

August 19, 2027

Conditions
Acute Lymphoblastic Leukemia
Interventions
DRUG

CD19 CAR-T cells injection

Lymphodepleting pre-treatment will begin one week before the CAR-T cell infusion to reduce the burden of abnormal immune cells in the body, creating a favorable environment for the infused CAR-T cells. The suggested pre-treatment regimen is based on the FC regimen (Fludarabine + Cyclophosphamide).After the pre-treatment, patients will undergo CAR-T cell infusion, where the genetically modified T-cells are infused back into the patient's body.

Trial Locations (2)

510200

RECRUITING

Zhujiang Hospital, Guangzhou

RECRUITING

Zhujiang Hospital, Guangzhou

All Listed Sponsors
lead

Zhujiang Hospital

OTHER

NCT07072494 - CD19 CAR-T Cell Infusion as Consolidation Therapy in Adolescent and Adult Patients With Acute B-ALL Ineligible for Allogeneic HSCT: A Clinical Study | Biotech Hunter | Biotech Hunter