NCT07071935View on ClinicalTrials.gov

A Pilot Randomized Clinical Trial of Early Ventilation in Amyotrophic Lateral Sclerosis (EVENT ALS)

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

November 30, 2025

Primary Completion Date

May 31, 2029

Study Completion Date

May 31, 2029

Conditions
Amyotrophic Lateral Sclerosis (ALS)Chronic Respiratory FailureNeuromuscular Disease PatientsNeuromuscular DiseaseRespiratory InsufficiencyRespiratory Insufficiency Requiring Mechanical VentilationPositive Pressure VentilationNon-invasive VentilationNon-invasive Ventilation SupportNon-invasive Ventilatory Support
Interventions
DEVICE

Non-invasive ventilation

Non-invasive ventilation will be started earlier than usual respiratory care guidelines for ALS in the United States.

Trial Locations (3)

17033

Penn State Hershey ALS Clinic, Hershey

19104

Penn Comprehensive ALS Center at Pennsylvania Hospital, Philadelphia

19107

Thomas Jefferson University Weinberg ALS Center, Philadelphi

All Listed Sponsors
collaborator

United States Department of Defense

FED

lead

University of Pennsylvania

OTHER