Quantification of Mitral Regurgitation Using 4D MRI Flow : Comparison With 2D MRI Flow and Echocardiography Using the Evolution of Left Ventricular Remodeling as a Reference

NANot yet recruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

April 30, 2028

Study Completion Date

April 30, 2028

Conditions
Mitral Regurgitation (MR)
Interventions
DIAGNOSTIC_TEST

Standard echocardiography

Routine ultrasound examination with standardized recordings for the study, incorporating volumetric assessment techniques

DIAGNOSTIC_TEST

2D phase-contrast magnetic resonance imaging

A cardiac MRI will be performed on a 1.5 Tesla system, including a biventricular function study with a series of short-axis slices, three long-axis slices, a 2D phase-contrast acquisition orthogonal to the aortic root. Additionally, standard T1 mapping sequences will be acquired on three short-axis slices, 15 minutes after the injection of 0.2 mmol/kg of body weight of gadolinium, for myocardial and blood T1 measurements.

DIAGNOSTIC_TEST

4D flow magnetic resonance imaging

A sagittal 4D flow acquisition lasting between 6 and 10 minutes of free breathing to cover all four cardiac chambers is added to the 2D acquisition.

DIAGNOSTIC_TEST

Cardiac ultrafast ultrasound imaging

Ultrafast sequences are added to the standard echocardiography acquisition.

Trial Locations (3)

75012

AP-HP - hôpital Saint-Antoine, Paris

75015

AP-HP - hôpital européen Georges-Pompidou,, Paris

92350

Groupe hospitalier Paris Saint-Joseph - hôpital Marie-Lannelongue, Le Plessis-Robinson

All Listed Sponsors
collaborator

Ministry of Health, France

OTHER_GOV

collaborator

GIRCI IDF

UNKNOWN

lead

Assistance Publique - Hôpitaux de Paris

OTHER

NCT07066904 - Quantification of Mitral Regurgitation Using 4D MRI Flow : Comparison With 2D MRI Flow and Echocardiography Using the Evolution of Left Ventricular Remodeling as a Reference | Biotech Hunter | Biotech Hunter