NCT07065539View on ClinicalTrials.gov

GnRH Agonist Pretreatment Duration and Letrozole Supplementation in Frozen Embryo Transfer for Adenomyosis Patients

NANot yet recruitingINTERVENTIONAL
Enrollment

432

Participants

Timeline

Start Date

July 20, 2025

Primary Completion Date

May 31, 2027

Study Completion Date

December 31, 2027

Conditions
Adenomyosis of UterusFrozen Embryo Transfer (FET)
Interventions
DRUG

GnRH-a-1M

Pre-treatment with one dose GnRH agonist before endometrial preparation.

DRUG

GnRH-a-2M

Pre-treatment with two doses GnRH agonist before endometrial preparation.

DRUG

GnRH-a+LE-1M

Pre-treatment with one dose GnRH agonist, along with daily 2.5 mg letrozole for 28 days before endometrial preparation.

DRUG

GnRH-a+LE-2M

Pre-treatment with two doses GnRH agonist, along with daily 2.5 mg letrozole for 28 days since the first injection of GnRH agonist before endometrial preparation.

Trial Locations (1)

510000

Reproductive Medical Center, the First Af liated Hospital of Sun Yat-sen University, Zhongshan 2nd Road, Number 1, Guangzhou

All Listed Sponsors
collaborator

Women and Children's Hospital of Fujian Province

UNKNOWN

collaborator

BoAi Hospital of Zhongshan

OTHER

lead

First Affiliated Hospital, Sun Yat-Sen University

OTHER