Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

PHASE3RecruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

July 22, 2025

Primary Completion Date

November 30, 2028

Study Completion Date

February 28, 2029

Conditions
Neovascular Age-Related Macular Degeneration (nAMD)
Interventions
BIOLOGICAL

4D-150 IVT (3E10 vg/eye)

If randomized to the 4D-150 treatment arm, 4D-150 will be administered at the assigned dose level as a single dose IVT injection on Day 1

BIOLOGICAL

EYLEA® (aflibercept) Injection 2 mg (0.05mL)

Eylea (aflibercept) will be administered at applicable visits

Trial Locations (24)

10032

NOT_YET_RECRUITING

New York Presbyterian Hospital - Columbia University Medical Center, New York

11590

RECRUITING

Vitreoretinal Consultants of NY, Westbury

21209

NOT_YET_RECRUITING

The Retina Care Center, Baltimore

21740

RECRUITING

Cumberland Valley Retina Consultants, Hagerstown

27511

RECRUITING

North Carolina Retina Associates, Cary

29464

NOT_YET_RECRUITING

Carolina Eyecare, Mt. Pleasant

29910

RECRUITING

Charleston Neuroscience Institute, LLC, Bluffton

30328

NOT_YET_RECRUITING

Thomas Eye Group, Sandy Springs

33617

RECRUITING

Retina Vitreous Associates of Florida, Tampa

34667

NOT_YET_RECRUITING

ClearVista Clinical Research, Hudson

37203

RECRUITING

Tennessee Retina, PC, Nashville

45242

NOT_YET_RECRUITING

Cincinnati Eye Institute, Cincinnati

75231

RECRUITING

Texas Retina Associate, Dallas

75703

RECRUITING

Tyler Retina Consultants, Tyler

79106

NOT_YET_RECRUITING

Southwest Retina Specialist - Panhandle Eye group, LLP, Amarillo

81303

RECRUITING

Southwest Retina Consultants, Durango

84107

RECRUITING

Rocky Mountain Retina Consultants, Salt Lake City

85351

RECRUITING

Barnet Dulaney Perkins Eye Center, Sun City

85704

RECRUITING

Retina Associates, Tucson

92835

RECRUITING

Retina Consultants of Orange County, Fullerton

94109

RECRUITING

West Coast Retina Medical Group, San Francisco

95008

RECRUITING

Retinal Diagnostic Center, Campbell

98383

RECRUITING

Pacific Northwest Retina, Silverdale

947401

RECRUITING

Verum Research, LLC, Eugene

Sponsors
All Listed Sponsors
lead

4D Molecular Therapeutics

INDUSTRY