A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.

PHASE3RecruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

August 5, 2025

Primary Completion Date

July 22, 2027

Study Completion Date

November 4, 2030

Conditions
Breast Cancer
Interventions
DRUG

PF-07248144

KAT6 inhibitor

DRUG

Fulvestrant

Endocrine therapy

DRUG

Everolimus

mTOR inhibitor

DRUG

Exemestane

Endocrine therapy

Trial Locations (8)

72703

NOT_YET_RECRUITING

Highlands Oncology Group, PA, Fayetteville

72758

NOT_YET_RECRUITING

Highlands Oncology Group, PA, Rogers

72762

NOT_YET_RECRUITING

Highlands Oncology Group, PA, Springdale

565-0871

RECRUITING

The University of Osaka Hospital, Suita

104-8560

RECRUITING

St. Luke's International Hospital, Chuo-ku

135-8550

NOT_YET_RECRUITING

The Cancer Institute Hospital of JFCR, Koto

142-8666

RECRUITING

Showa Medical University Hospital, Tokyo

00717

NOT_YET_RECRUITING

Ad-Vance Medical Research, Ponce

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY