60
Participants
Start Date
August 31, 2025
Primary Completion Date
August 31, 2026
Study Completion Date
December 31, 2026
Daily primaquine (0.5 mg/kg per day) for 14 days given with food food and water
Women will receive daily doses of PQ (0.5 mg/kg per day) for 14 days at a total treatment dose of 7 mg/kg PQ. All doses will be to the nearest full tablet, with food and water to prevent gastrointestinal discomfort, as directly observed treatment. Women vomiting within 30 minutes of administration of any dose will be re-treated.
Daily primaquine 1 mg/kg per day for 7 days given with food and water
Women will receive daily doses of PQ (1 mg/kg per day) for 7 days at a total treatment dose of 7 mg/kg PQ. All doses will be to the nearest full tablet, with food and water to prevent gastrointestinal discomfort, as directly observed treatment. Women vomiting within 30 minutes of administration of any dose will be re-treated.
Single-dose tafenoquine given with food and water to prevent gastrointestinal discomfort
Women will receive a single dose of 300mg tafenoquine. Treatment will be given with food and water to prevent gastrointestinal discomfort, as directly observed treatment. Women vomiting within 30 minutes of administration of any dose will be re-treated.
Alexishafen Health Centre, Madang
Menzies School of Health Research
OTHER
Papua New Guinea Institute of Medical Research
OTHER_GOV
Curtin University
OTHER