Accelerated TMS for Seizure-Type Functional Neurologic Disorders

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

September 2, 2025

Primary Completion Date

September 2, 2026

Study Completion Date

July 1, 2027

Conditions
Functional Neurological Symptom DisorderFunctional Seizures
Interventions
DEVICE

Transcranial Magnetic Stimulation

Participants will receive 6 to 10 sessions per day (i.e., theta burst; 600 pulses per session; 6000 pulses per day) over 3 to 5 treatment days using a MagVenture MagPro TMS System. Treatment will consist of a total of 30 sessions (18,000 total pulses). A single session is defined as 600 pulses at 50 Hz for 2s (i.e., 5 Hz triplets) and repeated every 10s for a total of 190s per session to l-dlPFC at 120% rMT with 15-minute intersession intervals. TMS will be targeted to Beam F3 for comparison to the bulk of the literature and to most mimic replicable clinical use.

Trial Locations (1)

29425

RECRUITING

Institute of Psychiatry, Brain Stimulation Department, Charleston

All Listed Sponsors
lead

Medical University of South Carolina

OTHER