Comparison of the Outcome of Treatment With Silymarin or N-Aceylcysteine in Patients Taking Anti-Tuberculous Drugs for Tuberculosis at a Tertiary Care Hospital , Karachi

PHASE1Not yet recruitingINTERVENTIONAL

Enrollment

410

Participants

Timeline

Start Date

July 31, 2025

Primary Completion Date

December 31, 2025

Study Completion Date

May 31, 2026

Conditions

Drug Induced Liver InjuryTuberculosis (TB)

Interventions

DRUG

Silymarin 420 mg

silymarin group received silymarin 140mg thrice daily along with antituberculous drugs for 14 days

DRUG

N Acetyl Cysteine

N- acetylcysteine group will receive N-acetylcysteine 900mg once daily with antituberculous drugs for 14 days

DRUG

Rifampicin (RMP) Ethambutol (E) Isoniazid (H) Pyrazinamid (Z)

Antituberculous drugs only

All Listed Sponsors

lead

Liaquat National Hospital & Medical College

OTHER