NCT07053072View on ClinicalTrials.gov

PD-1 mRNA LNP Vaccine for Advanced Primary Hepatocellular Carcinoma.

PHASE1/PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

July 15, 2025

Primary Completion Date

July 30, 2025

Study Completion Date

December 30, 2026

Conditions
PD-1 mRNA LNP VaccinePrimary Liver Cancer
Interventions
DRUG

Low Dose PD-1 mRNA LNP Vaccine

Patients will receive PD-1 mRNA LNP vaccine at 50 mcg weekly for the first 4 doses and a 5th dose 1 month after the 4th dose.

DRUG

Medium dose PD-1 mRNA LNP vaccines

Patients will receive PD-1 mRNA LNP vaccine at 75 mcg weekly for the first 4 doses and a 5th dose 1 month after the 4th dose.

DRUG

High dose PD-1 mRNA LNP vaccines

Patients will receive PD-1 mRNA LNP vaccine at 100 mcg weekly for the first 4 doses and a 5th dose 1 month after the 4th dose.

Trial Locations (1)

610041

West China Hospital, Sichuan University, Chengdu

All Listed Sponsors
lead

West China Hospital

OTHER