Individualizing Treatment for Asthma in Primary Care (Full Study)

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

3,200

Participants

Timeline

Start Date

August 1, 2025

Primary Completion Date

November 15, 2029

Study Completion Date

November 15, 2029

Conditions
AsthmaAsthma AttackAsthma Exacerbations
Interventions
DRUG

Inhaled corticosteroid (ICS)

Participants will use either a combination of budesonide/formoterol or mometasone/formoterol as both controller and rescue therapy or a stand alone inhaled steroid (beclomethasone, budesonide, fluticasone, mometasone, ciclesodine) of their choice with their current reliever therapy or be converted to budesonide/albuterol as rescue therapy.

DRUG

Azithromycin

Participants will take 500mg of azithromycin three times a week or 10mg/kg if under 50Kg which may be reduced to 250mg/Kg for side effects.

OTHER

Asthma Symptom Monitoring Web-based Application

All participants will be provided access to the Asthma Symptom Monitoring (ASM) tools. ASM can be integrated with electronic health records (EHR) or used as a stand alone application. Participants will answer 5 questions about their asthma each week. If symptoms are problematic, participants can request a call back from a person on their care team. Participants can view a graph of their data, watch videos, and record peak flows. Clinicians and members of the care team can view data in the EHR (not for stand alone web app).

Trial Locations (13)

10029

Mt. Sinai School of Medicine, New York

27599

University North Carolina, Chapel Hill

28207

Atrium Health, Charlotte

32803

AdventHealth, Orlando

65211

University of Missouri, Columbia

66160

University of Kansas, Kansas City

76104

JPS Health Network, Fort Worth

77005

Kelsey Research Foundation, Houston

80045

DARTNet Institute, Aurora

University Colorado-Denver, Aurora

98105

University of Washington, Seattle

01608

Reliant Medical Group, Worcester

08901

Rutgers Robert Wood Johnson Medical School, New Brunswick

Sponsors
All Listed Sponsors
collaborator

Penn State University

OTHER

collaborator

Icahn School of Medicine at Mount Sinai

OTHER

collaborator

University of Colorado, Denver

OTHER

collaborator

RAND

OTHER

collaborator

University of Washington

OTHER

collaborator

University of North Carolina

OTHER

collaborator

Reliant Medical Group

OTHER

collaborator

Kelsey Research Foundation

OTHER

collaborator

University of Kansas

OTHER

collaborator

University of Missouri-Columbia

OTHER

collaborator

John Peter Smith Health Network

UNKNOWN

collaborator

Rutgers University

OTHER

collaborator

AdventHealth

OTHER

collaborator

Wake Forest University Health Sciences

OTHER

lead

DARTNet Institute

OTHER_GOV