88
Participants
Start Date
November 1, 2025
Primary Completion Date
April 1, 2027
Study Completion Date
December 30, 2027
taVNS
Active or inactive non-invasive vagus nerve stimulation of the auricular branch of the vagus nerve paired with 2 oral feedings/day for 14d
NAC and taVNS
NAC 100 mg/kg diluted 1:3 with sterile water (or equal volume sterile water), q6h NG 1h before a feed for 4d prior to delivering active or sham taVNS paired with 2 feeds/day for 14d with NAC (or sterile water).
inactive taVNS
inactive transcutaneous auricular vagus nerve stimulation with 2 feeds/day x 14 days
sterile water and inactive taVNS
Sterile water per NG tube every 6h for 4 days, then continuing with 14days of inactive taVNS paired with oral feeding
Shawn Jenkins Children's Hospital, Medical University of South Carolina, Charleston
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
NIH
Medical University of South Carolina
OTHER