Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline

NARecruitingINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2026

Conditions
Mild Traumatic Brain InjuryPost Concussion Syndrome
Interventions
DEVICE

Functional near-infrared spectroscopy (fNIRS)

fNIRS is a non-invasive imaging technique which takes advantage of the light scattering and absorption differences between oxygenated (HbO) and de-oxygenated hemoglobin (HbDO) to characterize changes in cerebral hemodynamics in response to a given task or stimulus.

DEVICE

V1 stimulation electrodes

The V1 electrodes will be placed on the forehead with some gel and held in place with a headband or cap (a conductive adhesive gel may be placed under the electrodes to help with stimulation). Participants will receive short electrical stimulations through these electrodes that will differ in intensity.

DEVICE

Magnetic Resonance Imaging (MRI)

Participants will undergo 2 90-minute MRI sessions

Trial Locations (1)

53705

RECRUITING

University of Wisconsin - Madison, Madison

Sponsors
All Listed Sponsors
collaborator

Neuraworx Medical Technologies

UNKNOWN

lead

University of Wisconsin, Madison

OTHER

NCT07044596 - Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline | Biotech Hunter | Biotech Hunter