Spironolactone to Improve Pregnancy-Associated Hypertension Trajectories

PHASE2RecruitingINTERVENTIONAL
Enrollment

204

Participants

Timeline

Start Date

October 16, 2025

Primary Completion Date

December 2, 2027

Study Completion Date

March 2, 2029

Conditions
PreeclampsiaGestational Hypertension
Interventions
DRUG

spironolactone 25 mg orally once daily

Participants with hypertensive disorders of pregnancy will receive 25mg capsules of spironolactone to self-administer daily over the 12-week duration of the study treatment.

DRUG

Placebo tablet to match spironolactone

Participants with Hypertensive disorders of pregnancy will receive placebo equivalent capsules to self-administer daily over the 12-week duration of the study treatment.

Trial Locations (3)

15213

NOT_YET_RECRUITING

University of Pittsburgh Magee-Womens Hospital, Pittsburgh

02114

RECRUITING

Massachusetts General Hospital, Boston

02115

RECRUITING

Brigham and Women's Hospital, Boston

All Listed Sponsors
collaborator

Brigham and Women's Hospital

OTHER

collaborator

University of Pittsburgh Medical Center

OTHER

lead

Massachusetts General Hospital

OTHER