Interstitial Pneumonitis Associated With EGFR-TKI and Combined With PD-1/PD-L1

CompletedOBSERVATIONAL
Enrollment

67,818

Participants

Timeline

Start Date

January 1, 2015

Primary Completion Date

December 31, 2024

Study Completion Date

May 1, 2025

Conditions
Non-Small Cell Lung Cancer (NSCLC)
Interventions
DRUG

EGFR-TKI

epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)-including gefitinib, erlotinib, afatinib, and osimertinib

DRUG

PD-1/PD-L1 inhibitor

ICIs such as nivolumab, pembrolizumab, and atezolizumab-targeting the programmed cell death 1 (PD-1) or its ligand (PD-L1)

DRUG

EGFR-TKI combined with PD-1/PD-L1

epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs)-including gefitinib, erlotinib, afatinib, and osimertinib combined with ICIs such as nivolumab, pembrolizumab, and atezolizumab-targeting the programmed cell death 1 (PD-1) or its ligand (PD-L1)

All Listed Sponsors
lead

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

OTHER

NCT07036016 - Interstitial Pneumonitis Associated With EGFR-TKI and Combined With PD-1/PD-L1 | Biotech Hunter | Biotech Hunter