a Single Arm, Phase II Multicenter Clinical Trial to Evaluate the Efficacy and Safety of the Combination Therapy of Iparomlimab and Tuvonralima b and Chemotherapy ± Bevacizumab Induction Therapy Followed by Concurrent Chemoradiotherapy in Patients With Advanced Cervical Cancer .

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

July 1, 2025

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2029

Conditions
Cervical Cancer Stage IVACervical Cancer Metastatic
Interventions
COMBINATION_PRODUCT

2 cycles of combined drug induction therapy: every 3 weeks for 2 cycles; After ,synchronous radiotherapy and chemotherapy combined immunotherapy

The enrolled patients first receive 2 cycles of combined drug induction therapy: paclitaxel+cisplatin/carboplatin ± bevacizumab+QL1706, every 3 weeks for 2 cycles; After induction therapy, synchronous radiotherapy and chemotherapy combined with immunotherapy: extracorporeal irradiation+post loading radiotherapy+synchronous chemotherapy+immunotherapy. During radiotherapy, single agent cisplatin/carboplatin treatment for 5 courses per week+QL1706 treatment every 3 weeks for 3 courses; After the end of radiotherapy and chemotherapy, immune maintenance therapy will be administered for six months: treatment with QL1706 every 3 weeks for 9 courses, followed by a follow-up period until the end of radiotherapy for 2 years or death.

All Listed Sponsors
collaborator

Cancer Hospital of The University of Chinese Academy of Sciences

UNKNOWN

collaborator

Cancer Center of the First Affiliated Hospital of Soochow University

UNKNOWN

collaborator

The First Affiliated Hospital of Nanchang University

OTHER

collaborator

Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University

OTHER

collaborator

People's Hospital of Quzhou

OTHER

collaborator

First Affiliated Hospital of Ningbo University

NETWORK

collaborator

Wenzhou Central Hospital

OTHER

collaborator

Jinhua Municipal Central Hospital

OTHER

collaborator

First Hospital of Zhejiang University

UNKNOWN

collaborator

First Affiliated Hospital of Zhejiang University

OTHER

collaborator

Henan Provincial People's Hospital

OTHER

collaborator

Xiangya Hospital of Central South University

OTHER

lead

Zhejiang Cancer Hospital

OTHER