46
Participants
Start Date
July 1, 2025
Primary Completion Date
December 31, 2028
Study Completion Date
December 31, 2029
2 cycles of combined drug induction therapy: every 3 weeks for 2 cycles; After ,synchronous radiotherapy and chemotherapy combined immunotherapy
The enrolled patients first receive 2 cycles of combined drug induction therapy: paclitaxel+cisplatin/carboplatin ± bevacizumab+QL1706, every 3 weeks for 2 cycles; After induction therapy, synchronous radiotherapy and chemotherapy combined with immunotherapy: extracorporeal irradiation+post loading radiotherapy+synchronous chemotherapy+immunotherapy. During radiotherapy, single agent cisplatin/carboplatin treatment for 5 courses per week+QL1706 treatment every 3 weeks for 3 courses; After the end of radiotherapy and chemotherapy, immune maintenance therapy will be administered for six months: treatment with QL1706 every 3 weeks for 9 courses, followed by a follow-up period until the end of radiotherapy for 2 years or death.
Cancer Hospital of The University of Chinese Academy of Sciences
UNKNOWN
Cancer Center of the First Affiliated Hospital of Soochow University
UNKNOWN
The First Affiliated Hospital of Nanchang University
OTHER
Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University
OTHER
People's Hospital of Quzhou
OTHER
First Affiliated Hospital of Ningbo University
NETWORK
Wenzhou Central Hospital
OTHER
Jinhua Municipal Central Hospital
OTHER
First Hospital of Zhejiang University
UNKNOWN
First Affiliated Hospital of Zhejiang University
OTHER
Henan Provincial People's Hospital
OTHER
Xiangya Hospital of Central South University
OTHER
Zhejiang Cancer Hospital
OTHER