79
Participants
Start Date
June 29, 2025
Primary Completion Date
June 30, 2028
Study Completion Date
June 30, 2028
Intravenous esketamine using Dixon's up-and-down sequential method
Using Dixon's up-and-down sequential method, esketamine will be titrated intravenously from an initial 0.3 mg∙kg-1 dose with 0.02 mg∙kg-1 adjustments based on intraprocedural responses to pain (Positive: purposeful somatic movement or the complaint of pain; Negative: no movement or no complaint of pain). The titration sequence will continue until six crossover inflection points are observed.
Intravenous the dose of esketamine ED95
The intervention group will be injected with the dose of esketamine ED95.
Intravenous fentanyl 1 μg∙kg-1
The control group will be injected with fentanyl 1 μg∙kg-1.
Department of Anesthesiology, The First Affiliated Hospital of Xiamen University, 55 Zhenhai Road, Xiamen, China, Xiamen
The First Affiliated Hospital of Xiamen University
OTHER