A Study to Evaluate the Efficacy, Safety, Tolerability, Pharmacokinetic Characteristics, and Immunogenicity of Plonmarlimab in Subjects With Rheumatic and Immunological Disease-associated Haemophagocytic Lymphohistiocytosis (HLH) (Also Known as Macrophage Activation Syndrome (MAS))

PHASE2CompletedINTERVENTIONAL
Enrollment

18

Participants

Timeline

Start Date

April 7, 2023

Primary Completion Date

April 18, 2025

Study Completion Date

April 18, 2025

Conditions
Hemophagocytic Lymphohistiocytoses
Interventions
DRUG

Plonmarlimab

Subjects receive Plonmarlimab 6 mg/kg or 10 mg/kg, administered intravenously, once weekly for 8 weeks.

Trial Locations (6)

Unknown

Beijing Friendship Hospital, Capital Medical University, Beijing

Renji Hospital of Shanghai Jiaotong University School of Medicine, Shanghai

Beijing Peking Union Medical College Hospital, Beijing

Beijing Peking University People's Hospital, Beijing

The First Affiliated Hospital of Nanjing Medical University, Nanjing

Ruijin Hospital Of Shanghai Jiao tong University School of Medicine, Shanghai

All Listed Sponsors
lead

TJ Biopharma Co., Ltd.

INDUSTRY