Mezigdomide and Talquetamab in Relapsed and Refractory Multiple Myeloma

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

December 16, 2025

Primary Completion Date

July 1, 2027

Study Completion Date

July 1, 2028

Conditions
Relapsed Refractory Multiple Myeloma (RRMM)
Interventions
DRUG

Talquetamab

Talquetamab is injected under the skin (subcutaneously injected) by trained medical staff. During first cycle of talquetamab, the dose of talquetamab will increase until the goal dose (treatment dose) is reached (pre-determined dose escalation).

DRUG

Mezigdomide

Administered orally once per day (days 1-21 of applicable 28-day cycles; Days 1-7 of the 7-day Cohort B pre-phase cycle).

DRUG

Dexamethasone

Administered orally once per day, at the schedule outlined in the Arm Descriptions.

Trial Locations (3)

02114

Massachusetts General Hospital, Boston

02115

Beth Israel Deaconess Medical Center, Boston

02215

Dana-Farber Cancer Institute, Boston

All Listed Sponsors
collaborator

Celgene Corporation

INDUSTRY

collaborator

Janssen Research and Development LLC

UNKNOWN

lead

Massachusetts General Hospital

OTHER