25
Participants
Start Date
December 16, 2025
Primary Completion Date
July 1, 2027
Study Completion Date
July 1, 2028
Talquetamab
Talquetamab is injected under the skin (subcutaneously injected) by trained medical staff. During first cycle of talquetamab, the dose of talquetamab will increase until the goal dose (treatment dose) is reached (pre-determined dose escalation).
Mezigdomide
Administered orally once per day (days 1-21 of applicable 28-day cycles; Days 1-7 of the 7-day Cohort B pre-phase cycle).
Dexamethasone
Administered orally once per day, at the schedule outlined in the Arm Descriptions.
Massachusetts General Hospital, Boston
Beth Israel Deaconess Medical Center, Boston
Dana-Farber Cancer Institute, Boston
Collaborators (2)
Celgene Corporation
INDUSTRY
Janssen Research and Development LLC
UNKNOWN
Massachusetts General Hospital
OTHER