A Study to Evaluate Acalabrutinib, in Combination With the R-CHOP Standard of Care, for Previously Untreated Mantle Cell Lymphoma in Spain

PHASE2RecruitingINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

September 5, 2025

Primary Completion Date

June 15, 2027

Study Completion Date

December 15, 2028

Conditions
Mantle-cell Lymphoma
Interventions
DRUG

Acalabrutinib + R-CHOP standard of care

Acalabrutinib will be administered 100 mg twice per day (BID) orally (PO) until disease progression if medically appropriate, along with R-CHOP standard of care up to six 21-day cycles of the induction phase.

DRUG

Acalabrutinib combination with Rituximab

If the subject achieves response during the induction phase, acalabrutinib will be administered 100 mg BID PO until disease progression and rituximab 375 mg/m2 on Day 1 of every other 28-day cycle for a maximum of 12 additional doses.

DRUG

Acalabrutinib monotherapy

If the subject does not achive response during the induction phase, monotherapy acalabrutinib will be administered 100 mg BID PO until disease progression.

Trial Locations (22)

15006

RECRUITING

Research Site, A Coruña

20014

RECRUITING

Research Site, Donostia / San Sebastian

28005

RECRUITING

Research Site, Madrid

28006

NOT_YET_RECRUITING

Research Site, Madrid

28007

RECRUITING

Research Site, Madrid

28029

NOT_YET_RECRUITING

Research Site, Madrid

28222

WITHDRAWN

Research Site, Majadahonda

28922

RECRUITING

Research Site, Alcorcón

29010

NOT_YET_RECRUITING

Research Site, Málaga

33206

RECRUITING

Research Site, Gijón

36214

NOT_YET_RECRUITING

Research Site, Vigo

37007

NOT_YET_RECRUITING

Research Site, Salamanca

38010

RECRUITING

Research Site, Santa Cruz de Tenerife

39008

NOT_YET_RECRUITING

Research Site, Santander

41013

RECRUITING

Research Site, Seville

46010

RECRUITING

Research Site, Valencia

46017

RECRUITING

Research Site, Valencia

08916

RECRUITING

Research Site, Badalona

08035

RECRUITING

Research Site, Barcelona

08036

NOT_YET_RECRUITING

Research Site, Barcelona

09006

RECRUITING

Research Site, Burgos

07198

RECRUITING

Research Site, Palma de Mallorca

Sponsors

Lead Sponsor

All Listed Sponsors
collaborator

Apices Soluciones S.L.

INDUSTRY

lead

AstraZeneca

INDUSTRY