Supermicrosurgical Lymphaticovenous Anastomosis for Prevention of Upper Limb Lymphedema

NANot yet recruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

July 1, 2025

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2029

Conditions
Breast Cancer-Related LymphedemaLymphedemaBreast Cancer Invasive
Interventions
PROCEDURE

Immediate Distal Lymphaticovenous Anastomosis (ID-LVA)

ID-LVA (Immediate Distal Lymphaticovenous Anastomosis) is an supermicrosurgical technique performed during axillary lymph node dissection (ALND) to prevent breast cancer-related lymphedema, offering the dual advantages of immediate intervention and radiation-field avoidance. Compared to LYMPHA (Lymphatic Microsurgical Preventive Healing Approach), which utilizes proximal axillary anastomoses within the radiation field with larger vessels and higher venous pressure, ID-LVA creates precise anastomoses between 0.3-0.8mm distal superficial lymphatic vessels and low-pressure venules in the upper arm. In contrast to DD-LVA (Delayed Distal Lymphaticovenous Anastomosis) performed postoperatively (typically 4-12 weeks after ALND) for subclinical lymphedema, ID-LVA provides earlier prevention by utilizing undamaged lymphatics and avoids the need for a second procedure.

All Listed Sponsors
lead

Tianjin Medical University Cancer Institute and Hospital

OTHER