Sequential Treatments or Combinations Including Dasatinib, Quercetin, Fisetin and/or Temozolomide for the Treatment of Previously Treated Glioma With Residual Disease

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

August 12, 2025

Primary Completion Date

September 1, 2027

Study Completion Date

September 1, 2027

Conditions
Glioma
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood and CSF sample collection

DRUG

Dasatinib

Given PO

DRUG

Fisetin

Given PO

DRUG

Fluorodopa F 18

Undergo 18F-DOPA-PET scan

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

OTHER

Patient Observation

Receive rest and take no treatment

PROCEDURE

Positron Emission Tomography

Undergo 18F-DOPA-PET scan

DRUG

Quercetin

Given PO

DRUG

Temozolomide

Given PO

Trial Locations (1)

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Mayo Clinic

OTHER