Impact of SCFA Supplementation on Gut Microbiome Composition of Kidney Transplant Recipients

NAEnrolling by invitationINTERVENTIONAL
Enrollment

41

Participants

Timeline

Start Date

April 4, 2025

Primary Completion Date

September 4, 2025

Study Completion Date

September 4, 2025

Conditions
Metabolic EffectsImmunosuppressive AgentsRenal FunctionAdverse EventsGut MicrobiomeFlow CytometryImmune SystemMetabolome
Interventions
DIETARY_SUPPLEMENT

SCFA

Participants randomized to this group will receive 1000 mg of sodium butyrate daily for 12 weeks. The intervention aims to evaluate the effect of high-dose SCFA supplementation on the gut microbiome and systemic/urinary metabolome in kidney transplant recipients.

DIETARY_SUPPLEMENT

Placebo

Participants in this group will receive placebo capsules (sacharosis) identical in appearance to the active SCFA capsules, administered twice daily for 12 weeks. This arm serves as a control to evaluate the specific effects of SCFA supplementation.

Trial Locations (1)

03601

University Hospital Martin, Martin

All Listed Sponsors
collaborator

Comenius University

OTHER

lead

University Hospital, Martin

OTHER