Early Screening and Treatment of Heart Complication in Sickle Cell Disease

Deferoxamine is used to reduce excess iron accumulation after monitoring iron levels. Adjustment to therapy will be based on iron burden assessments throughout the study duration.

Deferasirox is used for iron chelation therapy based on iron burden assessment throughout the study.

Deferiprone is used for iron chelation therapy used throughout the study.

This device uses ultrasound waves to create images of heart to help evaluate the heart's structure and function. This allows the detection of abnormalities of heart due to iron overload through out the study.

The Electrocardiogram (ECG) device records the electrical activity of the heart. It is crucial for identifying arrhythmias and conduction abnormalities, which can be exacerbated by iron accumulation in the heart.