ctDNA-Guided Therapy for Relapsed/Refractory Hodgkin Lymphoma

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

October 31, 2028

Study Completion Date

April 30, 2033

Conditions
Hodgkin Lymphoma, AdultRefractory Hodgkin LymphomaClassic Hodgkin Lymphoma
Interventions
DRUG

Pembrolizumab

Given intravenously

RADIATION

Non-investigational, involved site radiotherapy (ISRT)

Undergo possible, standard of care, non-investigational radiation therapy

DRUG

Gemcitabine

Given IV

DRUG

Vinorelbine

Given IV

DRUG

Liposomal Doxorubicin

Given IV

DEVICE

Foresight CLARITY™ LDT

Foresight CLARITY LDT, a laboratory-developed test (LDT),by Foresight Diagnostics, is an ultra-sensitive liquid biopsy and tissue platform that detects MRD in patients with B-cell lymphomas

DRUG

Pegfilgrastim

Given IV for supportive care

PROCEDURE

Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET)/Computerized tomography (CT)

Undergo imaging

Trial Locations (6)

90095

Unversity of California, Los Angeles, Los Angeles

92093

University of California, San Diego, La Jolla

92617

University of California Irvine, Irvine

93701

University of California San Francisco-Fresno, Fresno

94143

University of California, San Francisco, San Francisco

95616

University of California Davis, Davis

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

UC Hematologic Malignancies Consortium (UCHMC)

UNKNOWN

collaborator

Foresight Diagnostics

UNKNOWN

collaborator

Gateway for Cancer Research

OTHER

lead

Michael Spinner, MD

OTHER