178
Participants
Start Date
November 28, 2024
Primary Completion Date
February 28, 2028
Study Completion Date
February 28, 2031
Anterior temporal lobectomy (ATL)
"Patients assigned to the experimental group will undergo an anterior temporal lobectomy (ATL) according to established protocols adapted from epilepsy surgery. ATL is a reproducible and anatomically well-defined procedure routinely performed in patients with pharmacoresistant temporal lobe epilepsy. On the non-dominant hemisphere, the neocortical resection typically extends 6.5 cm posteriorly from the temporal pole, while on the dominant side, the resection length is limited to 4.0 cm, both measured along the superior temporal gyrus and guided by the Sylvian fissure. Language dominance is determined based on handedness, as specified in the inclusion criteria. In most cases, the lateral neocortical segment can be removed en bloc.~The mesial component of ATL encompasses resection of the uncus, amygdala, and the anterior hippocampus, typically including both the head and body. Resection is carried out to the level of the tectal plate or, at minimum, to the lateral mesencephalic sulcus."
Gross Total Resection (GTR)
Patients will be surgically treated with GTR in terms of removing 100% of the tumor tissue in gadolinium-enhanced MRI.
RECRUITING
University Hospital Bonn, Bonn
University Hospital RWTH Aachen, Department of Neurosurgery
UNKNOWN
Kantonsspital Aarau, Department of Neurosurgery
UNKNOWN
University Hospital Bonn, Department of Neurosurgery
UNKNOWN
Dortmund Hospital, Neurosurgical Department
UNKNOWN
Helios Kliniken, Erfurt, Department of Neurosurgery
UNKNOWN
University Hospital Essen, Department of Neurosurgery and Spine Surgery
UNKNOWN
University Hospital Frankfurt, Department of Neurosurgery
UNKNOWN
University Hospital Giessen, Department of Neurosurgery
UNKNOWN
University Medical Center Göttingen, Department of Neurosurgery
UNKNOWN
University Medical Center Hamburg-Eppendorf, Department of Neurosurgery
UNKNOWN
Heidelberg University Hospital, Department of Neurosurgery
UNKNOWN
Jena University Hospital, Department of Neurosurgery
UNKNOWN
University of Cologne, Center of Neurosurgery Department of General Neurosurgery
UNKNOWN
University Hospital Leipzig, Department of Neurosurgery
UNKNOWN
University Medical Center Schleswig-Holstein/Lübeck, Department of Neurosurgery
UNKNOWN
Medical Faculty University Hospital Magdeburg, University Clinic for Neurosurgery
UNKNOWN
University Medical Center Mainz, Department of Neurosurgery
UNKNOWN
University Hospital Mannheim, Medical Faculty Mannheim, Department of Neurosurgery
UNKNOWN
Klinikum Rechts der Isar, Technical University of Munich, Department of Neurosurgery
UNKNOWN
LMU University Hospital, Department of Neurosurgery
UNKNOWN
University Hospital of Münster, Department of Neurosurgery
UNKNOWN
University Hospital Regensburg, Department of Neurosurgery
UNKNOWN
University Medical Centre Rostock, Department of Neurosurgery
UNKNOWN
University Hospital Tübingen, Department of Neurosurgery
UNKNOWN
University Hospital Ulm/Günzburg, University of Ulm, Department of Neurosurgery
UNKNOWN
Medical University of Vienna, Department of Neurosurgery
UNKNOWN
University Hospital, Bonn
OTHER