Study to Evaluate the Efficacy and Safety of Atezolizumab and Bevacizumab as Neoadjuvant Plus Adjuvant Treatment in HCC

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

November 30, 2025

Primary Completion Date

November 30, 2030

Study Completion Date

November 30, 2030

Conditions
Resectable Hepatocellular Carcinoma
Interventions
DRUG

Atezolizumab and Bevacizumab

"Participants will receive up to three 3 atezolizumab doses (days 10, 31, 52) and 2 bevacizumab dose (days 10 and 31) until surgery or unacceptable toxicity, whichever occurs first (neoadjuvant therapy).~The adjuvant therapy with Atezo + Bev will start between 4 and 12 weeks after the resection date, once the participant has fully recovered from the surgery. Participants will receive up to 12 months or 17 cycles of treatment, whichever occurs first, or until disease recurrence or unacceptable toxicity."

Trial Locations (13)

14004

Hospital Universitario Reina Sofía, Córdoba

15706

Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela

17007

Hospital Universitari Josep Trueta, Girona

28007

Hospital General Universitario Gregorio Marañón, Madrid

28034

Hospital Universitario Ramón y Cajal, Madrid

28040

Hospital Universitario Fundación Jiménez Díaz, Madrid

29010

Hospital Universitario Virgen de la Victoria, Puerto de la Torre

39008

Hospital Universitario Marqués de Valdecilla, Santander

46026

Hospital Universitario y Politécnico La Fe, Valencia

48903

Hospital Universitario de Cruces, Barakaldo

08916

Hospital Universitari Germans Trias i Pujol, Badalona

08907

Hospital Universitari de Bellvitge, Barcelona

Unknown

Hospital Universitari Vall d'Hebron, Barcelona

All Listed Sponsors
lead

Fundacion Clinic per a la Recerca Biomédica

OTHER