[18F]F-FAPI PET/CT and Laparoscopy in Staging Advanced Gastric Cancer

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

250

Participants

Timeline

Start Date

July 3, 2025

Primary Completion Date

January 31, 2028

Study Completion Date

January 31, 2029

Conditions
Locally Advanced Gastric AdenocarcinomaSTOMACH NEOPLASMGastric CancerPET-CT
Interventions
DIAGNOSTIC_TEST

[18F]FAPI-74 PET/CT

Patients included in the study will undergo FAPI-PET/CT after initial staging with gastroscopy and a contrast-enhanced CT of thorax and abdomen, but before undergoing a staging laparoscopy. Based on the results of the FAPI-PET/CT, the MDT and/or treating physician will decide on the next step: confirming possible malignant lesions on PET/CT by biopsies (either percutaneous of by staging laparoscopy), or in case of negative PET/CT, diagnostic laparoscopy.

DRUG

[18F]-FAPI-74

\[18F\]-FAPI-74 will be administered intravenously 60 minutes before PET/CT-scanning to be able to detect (metastases of) gastric cancer

Trial Locations (10)

Unknown

NOT_YET_RECRUITING

ZGT, Almelo

NOT_YET_RECRUITING

Amsterdam UMC, Amsterdam

NOT_YET_RECRUITING

Netherlands Cancer Institute - Antoni van Leeuwenhoek, Amsterdam

NOT_YET_RECRUITING

Rijnstate, Arnhem

NOT_YET_RECRUITING

Catharina Ziekenhuis, Eindhoven

NOT_YET_RECRUITING

Zuyderland, Geleen

NOT_YET_RECRUITING

UMC Groningen, Groningen

RECRUITING

Leids Universitair Medisch Centrum, Leiden

NOT_YET_RECRUITING

Erasmus MC, Rotterdam

NOT_YET_RECRUITING

UMC Utrecht, Utrecht

All Listed Sponsors
lead

Leiden University Medical Center

OTHER

NCT07018661 - [18F]F-FAPI PET/CT and Laparoscopy in Staging Advanced Gastric Cancer | Biotech Hunter | Biotech Hunter