A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System Lymphoma

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

65

Participants

Timeline

Start Date

October 31, 2025

Primary Completion Date

January 9, 2028

Study Completion Date

December 10, 2028

Conditions
Lymphoma
Interventions
DRUG

Rituximab

Specified dose on specified days

DRUG

Methotrexate

Specified dose on specified days

DRUG

Procarbazine

Specified dose on specified days

DRUG

Temozolomide

Specified dose on specified days

BIOLOGICAL

Liso-cel

Specified dose on specified days

DRUG

Fludarabine

Specified dose on specified days

DRUG

Cyclophosphamide

Specified dose on specified days

DRUG

Calcium folinate

Specified dose on specified days

Trial Locations (42)

10021

Local Institution - 301, New York

12203

Local Institution - 203, Berlin

13273

Local Institution - 112, Marseille

14263

Local Institution - 310, Buffalo

19104

Local Institution - 304, Philadelphia

20246

Local Institution - 209, Hamburg

21079

Local Institution - 106, Dijon

31059

Local Institution - 109, Toulouse

33600

Local Institution - 108, Pessac

34295

Local Institution - 107, Montpellier

35033

Local Institution - 101, Rennes

37075

Local Institution - 207, Göttingen

37203

Local Institution - 312, Nashville

44195

Local Institution - 302, Cleveland

45147

Local Institution - 206, Essen

50937

Local Institution - 204, Cologne

54500

Local Institution - 116, Vandœuvre-lès-Nancy

59037

Local Institution - 113, Lille

60611

Local Institution - 311, Chicago

67098

Local Institution - 115, Strasbourg

69120

Local Institution - 210, Heidelberg

69310

Local Institution - 103, Pierre-Bénite

70174

Local Institution - 201, Stuttgart

75010

Local Institution - 114, Paris

75013

Local Institution - 102, Paris

77030

Local Institution - 303, Houston

79038

Local Institution - 105, Rouen

79106

Local Institution - 202, Freiburg im Breisgau

80045

Local Institution - 305, Aurora

89070

Local Institution - 205, Ulm

92210

Local Institution - 110, Saint-Cloud

94305

Local Institution - 307, Stanford

98109

Local Institution - 306, Seattle

33612-9416

Local Institution - 308, Tampa

02214

Local Institution - 314, Boston

02215

Local Institution - 313, Boston

63110-1010

Local Institution - 316, St Louis

08901

Local Institution - 315, New Brunswick

43202-2224

Local Institution - 309, Columbus

06202

Local Institution - 111, Nice

44093 Cedex 1

Local Institution - 104, Nantes

09116

Local Institution - 208, Chemnitz

All Listed Sponsors
lead

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

INDUSTRY