Transfusion Reduction in High-Bleeding-Risk Cardiac Surgery With Desmopressin

PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

112

Participants

Timeline

Start Date

July 31, 2025

Primary Completion Date

July 31, 2027

Study Completion Date

August 31, 2027

Conditions
Adult Patients Undergoing Cardiac SurgeryHigh Bleeding RisksPlanned Elective Cardiac Surgery Using CPB
Interventions
DRUG

Placebo

Before induction of anesthesia, patients will receive identical and similar clear study solutions in similar size transparent 50-cc bags, including Saline will be infused over five hours at a rate of 10 ml/hr. The local pharmacists who will not be involved in patients' care or data collection will prepare the study solution.

DRUG

Desmopresin

Before induction of anesthesia, patients will receive identical and similar clear study solutions in similar size transparent 50-cc bags, including Desmopressin 0.3 ug/kg of the patient's body weight will be infused over five hours at a rate of 10 ml/hr. The local pharmacists who will not be involved in patients' care or data collection will prepare the study solution.

Trial Locations (1)

31952

Imam Abdulrahamn Bin Faisal University (Former, Dammam University), Dammam

All Listed Sponsors
collaborator

Johns Hopkins Aramco Healthcare

OTHER

lead

Imam Abdulrahman Bin Faisal University

OTHER