Nalbuphine Dosing and Its Impact on Anxiety and Depression in Ectopic Pregnancy Surgery

NANot yet recruitingINTERVENTIONAL
Enrollment

165

Participants

Timeline

Start Date

June 20, 2025

Primary Completion Date

October 22, 2025

Study Completion Date

October 30, 2025

Conditions
Ectopic PregnancyAnxietyDepressionNalbuphine
Interventions
DRUG

Nalbuphine 0.20mg/ml(total 30 mg)

In this group, participants will receive an intravenous infusion of Nalbuphine at a concentration of 0.20 mg/ml, which delivers a total of 30 mg over the course of 48 hours. Additionally, 10 mg of Metoclopramide will be administered to manage potential postoperative nausea. This intervention aims to assess the analgesic efficacy and its subsequent effect on psychological outcomes, specifically anxiety and depression, in patients undergoing surgery for ectopic pregnancy.

DRUG

Nalbuphine 0.27mg/ml(total 40 mg)

Participants assigned to this group will be treated with an intravenous infusion of Nalbuphine at a concentration of 0.27 mg/ml, resulting in a total dosage of 40 mg administered during the 48-hour postoperative period. They will also receive 10 mg of Metoclopramide to mitigate nausea and vomiting. This intervention is designed to evaluate the effectiveness of this dose in pain management and its influence on anxiety and depression levels post-surgery.

DRUG

Nalbuphine 0.33mg/ml(total 50 mg)

In this group, subjects will receive Nalbuphine at a concentration of 0.33 mg/ml, totaling 50 mg, delivered through intravenous infusion for 48 hours. Along with this, 10 mg of Metoclopramide will be included to address potential postoperative discomfort. This intervention seeks to explore how this higher concentration impacts pain relief and subsequent psychological effects, specifically targeting anxiety and depression following ectopic pregnancy surgery.

All Listed Sponsors
lead

Chengdu Jinjiang Maternity and Child Health Hospital

OTHER

NCT07009808 - Nalbuphine Dosing and Its Impact on Anxiety and Depression in Ectopic Pregnancy Surgery | Biotech Hunter | Biotech Hunter