A Multicenter, Prospective Study of Perioperative Finotonlimab Combined With Bevacizumab in Resectable Hepatocellular Carcinoma Patients With High-Risk Factors for Recurrence

NAActive, not recruitingINTERVENTIONAL
Enrollment

130

Participants

Timeline

Start Date

February 10, 2025

Primary Completion Date

April 28, 2028

Study Completion Date

October 28, 2028

Conditions
HCC
Interventions
DRUG

Finotonlimab (an anti-PD-1 monoclonal antibody) and Anbeizhu (a bevacizumab biosimilar)

First, perform a single session of TACE. Followed by three cycles of neoadjuvant therapy with Finotonlimab combined with bevacizumab. Proceed with curative resection. Finally, initiate postoperative adjuvant targeted-immunotherapy . Finotonlimab: intravenously every three weeks ,200mg. bevacizumab:intravenously every three weeks , with a dosage based on body weight: 15 mg (≤60 kg) .

PROCEDURE

TACE

Initial Perform a single session of TACE procedure.TACE treatment is strictly in accordance with the Chinese guidelines for clinical practice of transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (2023 Edition).

Trial Locations (1)

Unknown

Tongji Hospital, Wuhan

All Listed Sponsors
lead

Tongji Hospital

OTHER

NCT07009470 - A Multicenter, Prospective Study of Perioperative Finotonlimab Combined With Bevacizumab in Resectable Hepatocellular Carcinoma Patients With High-Risk Factors for Recurrence | Biotech Hunter | Biotech Hunter