Lifestyle Interventions to Prevent Cognitive Deficits in Subjects With Depressive Symptoms: From Mechanisms to Clinical Practice

NANot yet recruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

July 31, 2025

Primary Completion Date

August 31, 2026

Study Completion Date

March 31, 2028

Conditions
Major Depressive Disorder (MDD)Physical ActivityInflammationMetabolomeGut MicrobiotaDepressive Symptoms
Interventions
BEHAVIORAL

Mediterranean Diet

Participants will receive only the educational intervention about the Mediterranean diet. The program consists of 4-5 online sessions conducted by a nutritionist.

BEHAVIORAL

Physical Activity

In addition to educational sessions on the Mediterranean diet, there will be 2-3 weekly personalized exercise sessions, followed by a dedicated personal trainer at a partner gym. The treatment will last 12 weeks.

BEHAVIORAL

Cognitive Training

In addition to educational sessions on the Mediterranean diet, there will be one weekly cognitive training session in groups, supervised by qualified staff at the IRCCS FBF. The treatment will last for 12 weeks.

Trial Locations (1)

25125

IRCCS Centro San Giovanni di Dio Fatebenefratelli, Brescia

All Listed Sponsors
collaborator

Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)

OTHER

collaborator

University of Milan

OTHER

collaborator

China Medical University, China

OTHER

collaborator

University College Cork

OTHER

collaborator

Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

OTHER

lead

IRCCS Centro San Giovanni di Dio Fatebenefratelli

OTHER