Drug-drug Interaction Study of Omeprazole and Bemnifosbuvir/Ruzasvir

PHASE1CompletedINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

May 9, 2025

Primary Completion Date

June 28, 2025

Study Completion Date

June 28, 2025

Conditions
Healthy Volunteer Study
Interventions
DRUG

Treatment A-Bemnifosbuvir/Ruzasvir FDC administered fasting

On day 1 single 550 mg/180 mg dose BEM/RZR FDC (2 × 275 mg/90 mg FDC tablets) will be administered under fasting conditions.

DRUG

Treatment B-Omeprazole 20 mg dose administered fasting

On Day 4 to Day 13, a 20 mg dose omeprazole (1 × 20 mg) will be administered QD under fasting conditions.

DRUG

Treatment C-Bemnifosbuvir/Ruzasvir FDC administered simultaneously with 20 mg dose of Omeprazole fasting

On Day 8, a single 550 mg/180 mg dose BEM/RZR FDC (2 × 275 mg/90 mg FDC tablets) will be administered under fasting conditions simultaneously with a 20 mg dose omeprazole (1 × 20 mg).

DRUG

Treatment D-Bemnifosbuvir/Ruzasvir FDC administered 0.5 hour prior to 20 mg dose of Omeprazole

On Day 13, a single 550 mg/180 mg dose BEM/RZR FDC (2 × 275 mg/90 mg FDC tablets) will be administered 0.5 hour before the administration of a 20 mg dose omeprazole (1 × 20 mg).

DRUG

Treatment E-Omeprazole 40 mg administered fasting

On Day 14 to Day 22, a 40 mg dose omeprazole (2 × 20 mg) will be administered QD under fasting conditions.

DRUG

Treatment F-Bemnifosbuvir/Ruzasvir FDC administered 2 hours after 40 mg dose Omeprazole

On Day 18, a single 550 mg/180 mg dose BEM/RZR FDC (2 × 275 mg/90 mg FDC tablets) will be administered 2 hours after the administration of a 40 mg dose omeprazole (2 × 20 mg).

Trial Locations (1)

90630

Atea Study Site, Cypress

Sponsors
All Listed Sponsors
lead

Atea Pharmaceuticals, Inc.

INDUSTRY

NCT07007806 - Drug-drug Interaction Study of Omeprazole and Bemnifosbuvir/Ruzasvir | Biotech Hunter | Biotech Hunter