Smart Olfaction App to Reduce Relapse

EARLY_PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

132

Participants

Timeline

Start Date

October 17, 2025

Primary Completion Date

July 1, 2027

Study Completion Date

July 1, 2027

Conditions
Nicotine Dependence
Interventions
DEVICE

Ad Libitum Use followed by Instructed Use of the Inspire Device

Participants in this condition will use the novel olfactory stimulation delivery system (Inspire), to smell a specific order designed to assist with smoking cessation for 7 days. Participants will then be instructed to record every urge to smoke and report times when they think they might smoke in the smartphone-based smoking cessation app, Insight™. When urges above 0 are reported, the app will instruct participants to use the Inspire device. On day 8, participants will receive a notification on the smartphone-based smoking cessation app, Insight™, to switch to the Instructed Use condition. Participants will then be instructed to use the Inspire device only when participants report a cigarette craving about 0 at each of the surveys prompted from the smartphone-based smoking cessation app, Insight™.

DEVICE

Instructed Use followed by Ad Libitum Use of the Inspire Device

Participants in this condition will use the novel olfactory stimulation delivery system (Inspire), to smell a specific order designed to assist with smoking cessation for 7 days. Participants will be instructed to use the Inspire device only when participants report a cigarette craving about 0 at each of the surveys prompted from the smartphone-based smoking cessation app, Insight™. On day 8, participants will receive a notification on the smartphone-based smoking cessation app, Insight™, to switch to the Ad Libitum condition. Participants will then control how often they use Inspire and will be instructed to record every urge to smoke and report times when they think they might smoke in the smartphone-based smoking cessation app, Insight™.

DEVICE

Smart-T Smoking Cessation App with the Inspire Device Condition

Smart-T provides content during the pre-quit and post-quit periods to prepare and support participants during their quit attempts. Smart-T app contains multiple components, including an EMA delivery and data transfer system, automated messages based on EMA responses, and on-demand content. Participants will use Smart-T for 13 weeks. Participants will also use the Inspire device.

DEVICE

Smart-T Smoking Cessation App Without the Inspire Device Condition

Smart-T provides content during the pre-quit and post-quit periods to prepare and support participants during their quit attempts. Smart-T app contains multiple components, including an EMA delivery and data transfer system, automated messages based on EMA responses, and on-demand content. Participants will use Smart-T for 13 weeks.

DRUG

Nicotine replacement therapy (NRT)

NRT patches will be provided to assist with cravings and withdrawal symptoms following the quit attempts.

DEVICE

Inspire Device

The Inspire Device is a novel olfactory stimulation delivery system. It is a self-contained system with seven sealed chambers, with six gel matrix's that contain a distinct odor and one odorless gel matrix. Participants will press a button on the device to release an odor for participants to smell.

Trial Locations (1)

77204

RESTORE Laboratory: Research on Emotion, Substance Use Treatment Outcomes, Rehabilitation, and Empowerment, Houston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

University of Pittsburgh

OTHER

collaborator

University of Oklahoma

OTHER

collaborator

Brown University

OTHER

lead

University of Houston

OTHER