A Study to Assess Adverse Events, Change in Disease Activity of Intravenous Telisotuzumab Adizutecan in Combination With Osimertinib as First-Line Treatment in Adult Participants With Locally Advanced Unresectable or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

694

Participants

Timeline

Start Date

August 3, 2025

Primary Completion Date

December 31, 2031

Study Completion Date

December 31, 2031

Conditions
Non-Squamous Non-Small Cell Lung Cancer
Interventions
DRUG

Standard of Care

Standard of Care

DRUG

Telisotuzumab Adizutecan

Intravenous (IV) Infusion

DRUG

Osimertinib (Osi)

Oral Tablet

Trial Locations (18)

807

RECRUITING

Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 275293, Kaohsiung City

3084

RECRUITING

Austin Health /ID# 275505, Heidelberg

5011

RECRUITING

The Queen Elizabeth Hospital /ID# 275719, Woodville

6150

RECRUITING

St John Of God Murdoch Hospital /ID# 275700, Murdoch

28644

RECRUITING

Chungbuk National University Hospital /ID# 275768, Cheongju-si

32763

RECRUITING

Mid Florida Hematology And Oncology Center /ID# 275278, Orange City

48108

RECRUITING

Inje University Haeundae Paik Hospital /ID# 275388, Busan

50266

RECRUITING

The Iowa Clinic /ID# 276020, West Des Moines

68506

RECRUITING

Nho - Revive Research Institute /ID# 276115, Lincoln

89502

RECRUITING

Renown Regional Medical Center /ID# 276049, Reno

90033

RECRUITING

USC Norris Comprehensive Cancer Center /ID# 275343, Los Angeles

3525408

RECRUITING

Rambam Health Care Campus /ID# 274542, Haifa

4941492

RECRUITING

Rabin Medical Center /ID# 274540, Petah Tikva

5265601

RECRUITING

The Chaim Sheba Medical Center /ID# 274541, Ramat Gan

569-8686

RECRUITING

Osaka Medical And Pharmaceutical University Hospital /ID# 275684, Takatsuki

4710-243

RECRUITING

Unidade Local de Saude de Braga, EPE /ID# 275394, Braga

4099-003

RECRUITING

Unidade Local de Saude de Santo Antonio, E.P.E. /ID# 275387, Porto

4100-180

RECRUITING

Hospital Cuf Porto /ID# 275395, Porto

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AbbVie

INDUSTRY