BrECADD Therapy in Stage 2 B-IV Hodgkin Lymphoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

July 15, 2025

Primary Completion Date

July 15, 2030

Study Completion Date

July 15, 2030

Conditions
Hodgkin LymphomaAdvanced Hodgkin Lymphoma
Interventions
DRUG

Brentuximab Vedotin

Participants will receive 1.8 mg/kg of Brentuximab Vedotin intravenously (IV) for up to 30 minutes on Day 1 of each 21-day cycle period for up to 4 cycles in accordance with institutional procedures.

DRUG

Etoposide

Participants will receive 150 mg/m\^2 of Etoposide intravenously (IV) for up to 60 minutes on Days 1-3 of each 21-day cycle period for up to 4 cycles in accordance with institutional procedures.

DRUG

Cyclophosphamide

Participants will receive 1250 mg/m\^2 of Cyclophosphamide intravenously (IV) for up to 60 minutes on Day 1 of each 21-day cycle period for up to 4 cycles in accordance with institutional procedures.

DRUG

Doxorubicin

Participants will receive 40 mg/m\^2 of Doxorubicin intravenously (IV) for up to 30 minutes on Day 1 of each 21-day cycle period for up to 4 cycles in accordance with institutional procedures.

DRUG

Dacarbazine

Participants will receive 250 mg/m\^2 of Dacarbazine intravenously (IV) for up to 120 minutes on Days 2-3 of each 21-day cycle period for up to 4 cycles in accordance with institutional procedures.

DRUG

Dexamethasone

Participants will self-administer 40 mg of Dexamethasone orally on Days 1-4 of each 21-day cycle period for up to 4 cycles in accordance with institutional procedures.

Trial Locations (1)

33146

RECRUITING

University of Miami, Miami

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Pfizer

INDUSTRY

lead

University of Miami

OTHER